12/4/2023 0 Comments Mcf dire grove journal entries![]() ![]() IGF-I could induce PBK expression only in transformed cells, whereas epidermal growth factor could induce PBK in non-transformed MCF-10A breast epithelial cells. Here, we show that PBK is expressed at high levels in tumour cell lines compared with non-transformed cells. Among these was the serine/threonine kinase PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase), previously associated with highly proliferative cells and tissues. To identify new mediators of IGF-IR function in cancer, we recently isolated genes differentially expressed in cells overexpressing the IGF-IR. ![]() ![]() The contribution of the insulin-like growth-factor-I receptor (IGF-IR) to tumour progression is well documented.
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